Localisation of genetic markers and orientation of the linkage group on chromosome 19

Autor: Brook, J. D., Shaw, D. J., Meredith, L., Bruns, G. A. P., Harper, P. S.
Zdroj: Human Genetics; December 1984, Vol. 68 Issue: 4 p282-285, 4p
Abstrakt: A panel of human-rodent somatic cell hybrids containing translocation derivatives of human chromosome 19 has been used to assign the markers peptidase D, complement component 3, lysosomal mannosidase, lysosomal DNAase, chorionic gonadotropin ß-subunit, and a new polymorphic DNA sequence, to specific regions of chromosome 19. This has allowed the relative orientations of the genetic and physical maps to the established, and provides the framework for a search for the genes responsible for inherited disorders on chromosome 19, such as myotonic dystrophy and neurofibromatosis.
Databáze: Supplemental Index