| Abstrakt: |
This paper describes the determination of the H-Y antigen in cells obtained from amniotic fluids of two male and two female fetuses found to be normal at birth, and from another fetus that was suspected to have a karyotype 46,XY,t(15;Y) by Q banding. Since the area of the Y chromosome where the H-Y antigen gene appears to be located on the chromosomal material was suspected to be involved in the translocation, it was thought that this fetus could have a double dose of H-Y antigen as seen in 47,XYY individuals. The fetus was found to have a normal dose of the antigen and a normal 46,XY karyotype. The extra material on chromosome 15 was found to be NOR (nuclear organizer region) and to be present in his father's karyotype. The possibility of this determination in other inherited conditions is discussed. |
Full text from SpringerLink