| Autor: |
Martigne, P., Fauvelle, F., Diserbo, M., Cretallaz, C., Follot, S., Amourette, C. |
| Zdroj: |
Radioprotection; January 2008, Vol. 43 Issue: 5 |
| Abstrakt: |
Puropose : In the event of an acute total-body irradiation, whatever it is therapeutic or accidental, the physiopathology explaining the long-term neurological effects is unknown. We have developed a model of adult rats for which frequent behavioral assays were performed before and after a non-lethal whole-body ionizing radiation (60Co, 4,5 Gy). Learning and memory processing is an aspect of cognition involving mainly the hippocampus. We used high-resolution magic angle spinning (HRMAS) 1H NMR spectroscopy to characterize the biochemistry of four specific brain regions. The biological data for each animal will be compared to their behavioral performances, in order to underline any possible correlations. The best understanding of the physiopathological process in the Central Nervous System (CNS) will allow determining some prevention means or some enhancements for the radio-induced neurological late effects. |
| Databáze: |
Supplemental Index |
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