| Autor: |
Fedorov, N. B., Sergeeva, O. A., Skrebitsky, V. G. |
| Zdroj: |
Experimental Brain Research; June 1993, Vol. 94 Issue: 2 p270-272, 3p |
| Abstrakt: |
Hebb-type plastic changes of synaptic trans mission were analyzed in the Schäffer collateralcommissural pathways (SC) of the mouse hippocampal slice. Low frequency (0.05–0.1 Hz) SC stimulation (S2) was paired with intracellular depolarization (100–200 ms; 2–3 nA) of CA1 pyramidal. Postpairing facilitation of synaptic responses in picrotoxin-free medium occurred only when S2 was “primed” with neurons the preceding shock (S1) administered through the same electrode 200 ms before S2. Priming-determined disinhibition in local circuitry is supposed to be responsible for this phenomenon. |
| Databáze: |
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