Is the airway epithelium responsible for histamine metabolism in the trachea of guinea pigs?

Autor: Lindström, E. G., Andersson, R. G. G., Granérus, G., Grundström, N.
Zdroj: Inflammation Research; May 1991, Vol. 33 Issue: 1-2 p170-172, 3p
Abstrakt: The aim of the study was to investigate whether or not the epithelium plays an active role in histamine metabolism, via the histaminase and/or methyltransferase pathways. Isolated tracheas from guinea pigs sensitized to egg albumin (EA) were used. The epithelium was either left intact or removed from the preparations. The tracheal tubes were mounted in a chamber, allowing estimation of smooth muscle tension, and perfused with buffer. In some experiments the perfusate was collected for determination of histamine and methylhistamine.
Databáze: Supplemental Index