Differential inhibition by nedocromil sodium of superoxide generation elicited by platelet activating factor in human neutrophils

Autor: Rubin, R. P., Thompson, R. H., Naps, M. S.
Zdroj: Inflammation Research; November 1990, Vol. 31 Issue: 3-4 p237-242, 6p
Abstrakt: Nedocromil sodium (10−10–10−9M) produced a dose-related inhibition of superoxide anion generation induced by platelet activating factor (PAF) in human polymorphonuclear leukocytes (PMNs). At a higher concentration (3×10−7M), nedocromil sodium significantly inhibited superoxide generation elicited by N-formyl-methionyl-leucylphenylalanine, but was unable to block the response to phorbol dibutyrate. Nedocromil sodium (10−11–10−5M) enhanced PAF-stimulated lysozyme release in a non-concentration-dependent manner, and was completely ineffective in depressing PAF-induced release of [3H]arachidonic acid and the rise in cytosolic Ca2+. The preferential inhibitory effects of nedocromil sodium on PAF-induced activation of superoxide generation may provide insight into the therapeutic action of this drug as an anti-asthmatic agent.
Databáze: Supplemental Index
Externí odkaz: