| Autor: |
Schultheis, A. H., Bassett, D. J. P. |
| Zdroj: |
Inflammation Research; September 1991, Vol. 34 Issue: 1-2 p270-273, 4p |
| Abstrakt: |
As a model of non-immunological lung inflammation, guinea pigs were exposed to 2.0 ppm ozone for 4 hours. Polymorphonuclear leukocytes (PMNs) rapidly accumulated in lung interstitium but declined from 147±34 million cells to control values (33±6 million cells) within the first 24 hours. Bronchoalveolar lavage (BAL) recovered PMNs were maximal by 3–6 hours (4±1 million cells) and remained elevated for 3 days. Macrophage numbers were doubled in lavageable spaces but those in interstitium increased by only a third at 2 days post-exposure. By 7 days post-exposure BAL macrophages had declined to control values of 12±2 million cells while those in interstitium remained elevated through 14 days. These data demonstrate that BAL does not necessarily reflect cellular changes in lung interstitium. |
| Databáze: |
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