| Autor: |
Weithmann, K. U., Jeske, S., Schlotte, V. |
| Zdroj: |
Inflammation Research; May 1994, Vol. 41 Issue: 3-4 p164-170, 7p |
| Abstrakt: |
Leflunomide exerts its effects primarily via the immunomodulating and antiphlogistic activities of its major metabolite A 77 1726. Our investigation in several eicosanoid forming systems revealed that in human white blood cells the metabolite did not cause any alteration on Ca-ionophore stimulated metabolism of membrane bound arachidonic acid to cis-, trans- and epi-LTB4. Thus, the involved enzyme systems phospholipase A2, 5-lipoxygenase and LTA4-hydrolase can be ruled out as a target of the drug. However, in several cellular systems the drug weakly inhibited the generation of 5-HETE and LTB4 from exogenous arachidonic acid, possibly by interfering with the exogenous substrate's access to the 5-lipoxygenase. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
|
Full text from SpringerLink