| Autor: |
Taniai, Hiroko, Nishiyama, Takeshi, Miyachi, Taishi, Imaeda, Masayuki, Sumi, Satoshi |
| Zdroj: |
American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics: The Official Publication of the International Society of Psychiatric Genetics; September 2008, Vol. 147 Issue: 6 p844-849, 6p |
| Abstrakt: |
An investigation of genetic structures underlying autistic traits was performed with samples from twins for which at least one proband had been ascertained as having autism spectrum disorders ASDs in our catchment area. In order to adjust for recent concepts of autism, we employed criteria for the broad spectrum of disease and the childhood autism rating scale CARS for quantitative assessment. The CARS test was performed on 45 twin pairs 19 monozygotic, 26 dizygotic detected with a regional routine screening system. The obtained CARS scores were subjected to structural equation modeling SEM, incorporating sex differences for each causal influence ascertainment correction, using the Mx software. A best fitting model of causal influences on autistic traits measured continuously, incorporating additive genetic A and nonshared environmental influences E, was generated. With this AE model, the estimated heritability was 0.73 for males and 0.87 for females, based on the continuous CARS scores. There was no evidence for the existence of sexspecific genetic influences. Autistic traits were highly heritable in twins with even broad spectrum of autism, corresponding to the results of early studies based on classical autism. Additive genetic factors were more influential in females than males. © 2008 WileyLiss, Inc. |
| Databáze: |
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