| Autor: |
Zimmerman, B. J., Gaginella, T. S., Granger, D. N. |
| Zdroj: |
Inflammation Research; September 1992, Vol. 37 Issue: 1-2 p80-84, 5p |
| Abstrakt: |
This study demonstrates that SC-41930, 7-[3-(4-acetyl-3-methoxy-2-propylphenoxy)-propoxy]-3,4-dihydro-8-propyl-2H-1-benzopyran-2-carboxylic acid, an orally active LTB4 receptor antagonist, reduces LTB4-induced leukocyte adhesion and emigration in rat mesenteric venules. The mesentery of Sprague-Dawley rats was prepared for intravital microscopic examination and venules of 25–35 μm were chosen for evaluation. In control animals, LTB4 (20nM) was superfused over the mesentery for 30 min. In the treatment group SC-41930 (5 μM) was superfused for 30 min, followed by a 30 min superfusion with SC-41930 and LTB4. The LTB4-induced increase in leukocyte adherence and emigration in postcapillary venules was significantly attenuated by pretreatment with SC-41930. Other experiments demonstrated that platelet-activating-factor-induced leukocyte adherence was not affected by SC-41930. These results indicate that SC-41930 is a potent inhibitor of LTB4-induced leukocyte-endothelial cell adhesive interactions in postcapillary venules. |
| Databáze: |
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