| Autor: |
DiMartino, M. J., Wolff, C. E., Campbell, G. K., Hanna, N. |
| Zdroj: |
Inflammation Research; June 1989, Vol. 27 Issue: 3-4 p325-327, 3p |
| Abstrakt: |
Arachidonic Acid (AA) injected into a hindpaw of Lewis rats produces high levels of tissue myeloperoxidase (MPO), a biochemical marker for PMN leukocytes. Treatment with a corticosteriod (prednisolone) or dual 5-LO/CO inhibitors of AA metabolism (phenidose, SKF 86002) produced dose-related inhibition of AA-induced elevations in paw tissue MPO levels. In contrast, administration of high pharmacologic doses of selective cyclooxygenase inhibitors (indomethacin, ibuprofen, naproxen), anti-histamine/serotonin agents (cyproheptadine, chlorpheniramine) or an anti-arthritic gold compound (auranofin) produced only slight or moderate effects. Thus, AA-induced hindpaw inflammation is a useful method for determining pharmacologic effects of 5-LO/CO inhibitors on PMN leukocyte infiltrationin vivo. |
| Databáze: |
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