| Autor: |
De Clerck, F., Somers, Y., Van Gorp, L. |
| Zdroj: |
Inflammation Research; December 1984, Vol. 15 Issue: 5-6 p627-635, 9p |
| Abstrakt: |
5-Hydroxytryptamine (5-HT) is implicated in the platelet-vessel wall interactions during hemostasis. Indeed, the tall bleeding time and the initial blood loss in rats are significantly increased by platelet amine depletion with reserpine/parachlorophenylalanine, by the specific 5-HT2 receptor antagonists ketanserin, R 55 667 and R 56 433 and by the ergot derivatives metergoline and methysergide. In the dose range affecting hemostasis, the serotonergic receptor antagonists also inhibit the 5-HT-amplified aggregation of ADP-sensitized platelets in rat whole blood. Bleeding times are also prolonged by α-adrenergic receptor antagonism with prazosin or phentolamine, by specific thromboxane A2-synthetase inhibition with R 59 655 or dazoxiben, and by anticoagulant treatment. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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