| Autor: |
Nowak, Jerzy Z., Maslinski, Czeslaw |
| Zdroj: |
Inflammation Research; April 1986, Vol. 18 Issue: 1-2 p145-148, 4p |
| Abstrakt: |
The specific binding of different amounts of3H-mepyramine to the bovine retina revealed a quasi-hyperbolic curve which approached saturation at3H-ligand concentration over 9–12 nM. Scatchard analysis of the binding data showed two binding sites with KD values of 0.76 nM and 7.3 nM and Bmax of 49.3 and 194.6 fmole/mg protein, respectively. In the guinea-pig brain3H-mepyramine bound to a single population of binding sites with KD value of 1.6 nM and Bmax of 291 fmole/mg protein. Various H1-antihistamines were potent competitors of the3H-mepyramine binding: there was a big difference in potency of d- and 1-chlorpheniramine in both membrane preparations. |
| Databáze: |
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| Externí odkaz: |
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