The enthalpimetric determination of inhibition constants for the competitive inhibition of serum cholinesterase by morphine, quinine and procaine

Autor: Tan, B., Grime, J. K.
Zdroj: Journal of Thermal Analysis and Calorimetry; August 1981, Vol. 21 Issue: 2 p367-373, 7p
Abstrakt: A method is described for the enthalpimetric determination of inhibition constants based on a previously reported procedure for the determination ofKm, using the integrated Michaelis-Menten equation. The inhibition of the cholinesterase-catalyzed hydrolysis of butyryl-choline by morphine, quinine and procaine is chosen as a model. The results compare favourably with Lineweaver-Burk data.
Databáze: Supplemental Index
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