| Autor: |
Heine, D., Passmore, H. C., Patel, V., Shultz, L. D., Ward-Bailey, P., Cook, S. A., Davisson, M. T. |
| Zdroj: |
Mammalian Genome; July 1996, Vol. 7 Issue: 7 p497-500, 4p |
| Abstrakt: |
The goal of this study was to determine the effect of the mouse severe combined immunodeficiency (scid) mutation on the rate of meiotic recombination, by standard backcross linkage analysis. For this purpose, we examined four crosses that involved F1hybrid animals heterozygous for the strain C57BL/6 and BALB/c genomes. In one set of reciprocal crosses, F1animals were homozygous scid/scid, and in a second set of reciprocal crosses, F1mice were homozygous wild-type (+/+) at the scidlocus. Backcross progeny were typed for recombination between selected genetic markers on mouse Chromosomes (Chrs) 1, 4, 6,7, 9, 15, and 17. Although some differences in recombination were observed over some intervals, the expression of the SCID phenotype did not appear to have a major or consistent effect on meiotic recombination. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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