| Autor: |
Wegerhof, Paul H., Wenk, Peter |
| Zdroj: |
Parasitology Research; February 1979, Vol. 60 Issue: 1 p55-64, 10p |
| Abstrakt: |
A single injection ofLitomosoides carinii microfilariae — harvested from female adult worms (uterus microfilariae) or isolated from blood of infected cotton rats (blood microfilariae) — into normal, uninfected female cotton rats resulted in a quantitatively demonstrable microfilaraemia. The longevity of injected blood microfilariae was estimated as more than 49 days. Uterus microfilariae were present in the circulating blood for more than 28 days. The maximum microfilaraemia was dose-dependent when blood microfilariae were injected subcutaneously. After single intravenous or intraperitoneal injection of both types of microfilariae the recovery rates differed depending on the mode of injection. Intravenously injected blood microfilariae caused the highest microfilaraemia initially. Intraperitoneal injected uterus and blood microfilariae resulted in a parasitaemia lasting for 35 and 56 days respectively. Second challenge injections caused a different microfilaraemia according to the type of microfilariae and the mode of primary injection. Acquired resistance could be confirmed for challenge injections especially when uterus microfilariae were inoculated subcutaneously. On the other hand, blood microfilariae were able to induce only a low resistance of the host against injected microfilariae. The observed resistance was due to the uterus microfilariae themselves or the other embryonic stages injected with the fully developed uterus microfilariae and even acted against both uterus and blood microfilariae. |
| Databáze: |
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