Effect of the timing of cefuroxime dosage on its protection of rats against gentamicin nephrotoxicity

Autor: Capel-Edwards, K., Atkinson, R. M., Wheeldon, J. M., Pratt, D. A. H., Patterson, G. G., Harman, I. W., Foord, R. D.
Zdroj: Infection; January 1980, Vol. 8 Issue: 1 p41-42, 2p
Abstrakt: Summary The nephrotoxic effect on rats of once daily treatment with 40 or 45 mg gentamicin/kg/day for ten days was substantially reduced by administration of 4 g cefuroxime/kg/day, either at the same time or eight hours later. This dosage of cefuroxime was protective when given for only two consecutive days starting on the first to third days of gentamicin treatment, but enhanced gentamicin nephrotoxicity when started on the sixth or subsequent days.
Databáze: Supplemental Index