The effect of induced metabolic acidosis on vitamin D3 metabolism in rachitic chicks

Autor: Sauveur, B., Garabedian, M., Fellot, C., Mongin, P., Balsan, S.
Zdroj: Calcified Tissue International; December 1977, Vol. 23 Issue: 1 p121-124, 4p
Abstrakt: Summary The metabolism of vitamin D3 was studied in 3-week-old, vitamin D deficient chicks, fed since hatching with a diet containing 3% ammonium chloride, 1% calcium, and 0.7% phosphorus. When kidney homogenates were incubated in vitro with [3H]25-(OH)D3, the production of 1,25-(OH)2D3 was reduced by 40% in acidotic birds. During in vivo experiments, after injection of [3H]D3 (1220 pM/bird), the level of 1,25-(OH)2D3 was also reduced in blood plasma, intestine, and tibiae in acidotic chicks as compared with the controls. As a large increase in plasma phosphate was found during acidosis, these results are discussed in relation to the possible role of phosphorus in the control of 1,25-(OH)2D3 synthesis.
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