| Autor: |
Castro, Gerardo D., Díaz Gómez, María I., Castro, José A. |
| Zdroj: |
Archives of Toxicology; April 1991, Vol. 65 Issue: 4 p340-343, 4p |
| Abstrakt: |
Chemically or enzymatically generated trichloromethyl free radicals interact with liposoluble derivatives of phenylalanine. In vitro, in a chemical system to produce ·CCl3 (benzoyl peroxide catalysis), this radical attacked N-acetyl-d,l-phenylalanine methyl ester (PheMeAc) to give a monochlorinated derivative (I) and an unsaturated imine type derivative of PheMeAc (II). Using a liver microsomal system to produce ·CCl3 (microsomes + NADPH + CCl4 under nitrogen), the attack of PheMeAc did not result in I or II formation, but in production of benzene. The phenylalanine content in liver microsomal proteins from rats treated with CCl4 6 h before, was not significantly decreased. The results suggest that phenylalanine is a potential target of ·CCl3. |
| Databáze: |
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| Externí odkaz: |
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