| Autor: |
Kirch, D. G., Alexander, R. C., Suddath, R. L., Papadopoulos, N. M., Kaufmann, C. A., Daniel, D. G., Wyatt, R. J. |
| Zdroj: |
Journal of Neural Transmission; October 1992, Vol. 89 Issue: 3 p219-232, 14p |
| Abstrakt: |
Summary The ratio of albumin in cerebrospinal fluid (CSF) to serum may serve as an index of the integrity of the blood-CSF barrier, with increases in this ratio indicating increased permeability. The ratio of immunoglobulin G (IgG) in CSF to serum (divided by the albumin ratio to correct for variance in blood-CSF permeability) represents an index of the endogenous production of IgG in the central nervous system (CNS), with increases reflecting a possible infectious and/or autoimmune process stimulating central IgG synthesis. We analyzed simultaneously collected CSF and serum samples from 46 schizophrenic subjects, 8 of whom were studied both on and off neuroleptic treatment, and samples from 20 normal controls. The data indicated increases in CSF/ serum albumin ratios or CSF/serum IgG indices in 22% and 20%, respectively, of the schizophrenic patients. Only 3 patients showed elevations in both indices. Comparison of values on and off neuroleptics indicated no significant effect of neuroleptics on these indices. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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