A 23187-stimulated calcium uptake and GABA release by cerebrocortical synaptosomes: effects of high pressure

Autor:	Gilman, S. C., Colton, J. S., Grossman, Y.
Zdroj:	Journal of Neural Transmission; February 1991, Vol. 86 Issue: 1 p1-9, 9p
Abstrakt:	Summary Guinea pig cerebrocortical synaptosome preparations were used to study the effect of compression to 62 ATA on⁴⁵Ca²⁺ uptake and [³H]GABA release using a calcium ionophore A23187, which bypasses the voltage-sensitive calcium channel. Pressure was found to exert a suppressive effect on the A 23187-induced release of [³H]GABA, while having no significant effect on A 23187-stimulated⁴⁵Ca²⁺ uptake. On the other hand, both depolarization-induced⁴⁵Ca²⁺ uptake and [³H]GABA release were inhibited by pressure exposure. These results suggest that pressure may suppress GABA release by affecting pre-synaptic events subsequent to calcium influx.
Databáze:	Supplemental Index
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