| Autor: |
Sun, C. J., Johannessen, J. N., Gessner, W., Namura, I., Singhaniyom, W., Brossi, A., Chiueh, C. C. |
| Zdroj: |
Journal of Neural Transmission; June 1988, Vol. 74 Issue: 2 p75-86, 12p |
| Abstrakt: |
Summary Unilateral intranigral administration of the oxidative metabolites of 1-methyl-4-pheny1-1,2,3,6-tetrahydropyridine (MPTP), 1-methyi-4-phenyl-dihydropyridine (MPDP+) or l-methyl-4-phenylpyridine (MPP+) produced dose-dependently a depletion of dopamine in the ipsilateral striatum of rats two weeks following treatment.d- Amphetamine and apomorphine induced circling toward the lesioned side in these unilaterally treated animals. No contralateral circling behavior was observed after challenging with apomorphine. This dopamine lesioning effect of MPP+ was not blocked by pretreatment of animals with a dopamine uptake blocker, GBR 12909. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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