Anti-serotonergic effects of urethane and chloral hydrate may not be mediated by a blockade of 5-HT2 receptors

Autor: Dringenberg, H. C., Baker, G. B., Urichuk, L. J., Vanderwolf, C. H.
Zdroj: Journal of Neural Transmission; June 1996, Vol. 103 Issue: 6 p693-698, 6p
Abstrakt: Summary The general anesthetics urethane and chloral hydrate have profound anti-serotonergic effects both in the rat cortex in vivo and the rat aortic ring in vitro. The suggestion that these effects may be due to an action on 5-HT2 receptors was tested using ex vivo and in vitro [3H]ketanserin binding assays with membrane-enriched fractions from rat brain. Urethane did not alter [3H]ketanserin binding in the ex vivo assay. In the in vitro assay, urethane, chloral hydrate, and its active metabolite 2,2,2-trichloroethanol produced slight reductions (of 16%, 9%, and 18%, respectively) of [3H]ketanserin binding. These studies suggest that anti-serotonergic effects of urethane and chloral hydrate may not be mediated by a blockade of 5-HT2 receptors.
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