Effects of internal and external sodium on the sodium current-voltage relationship in thesquid giant axon

Autor: Landowne, D., Scruggs, V.
Zdroj: Journal of Membrane Biology; June 1981, Vol. 59 Issue: 2 p79-89, 11p
Abstrakt: Summary The early transient current-voltage relationship was measured in internally perfused voltage clamped squid giant axons with various concentrations of sodium on the two sides of the membrane. In the absence of sodium on either side there is an outward transient current which is blocked by tetrodotoxin and varies with internal potassium concentration. The current increases linearly with voltage for positive potentials. Adding sodium ions internally increases the slope of the current-voltage relationship. Adding sodium ions externally also increases the slope between +10 and +80 mV. Adding sodium to both sides produces the sum of the two effects.
Databáze: Supplemental Index