| Autor: |
Gullapalli, Sharada, Shivaswamy, Vidya, Ramasarma, T., Kurup, C. K. Ramakrishna |
| Zdroj: |
Molecular and Cellular Biochemistry; October 1989, Vol. 90 Issue: 2 p155-164, 10p |
| Abstrakt: |
Mitochondria isolated from the livers of rats administered with sodium meta-, ortho-, or polyvanadate, but not vanadyl sulphate, exhibited enhanced Ca2+ — stimulated respiration and uptake of calcium. These effects were shown also by mitochondria isolated from livers perfused with polyvanadate. The concentration of acid-soluble calcium decreased significantly in the mitochondrial fraction on vanadate treatment, while that in the cytosol showed a corresponding increase. Phenoxybenzamine, an antagonist to a-adrenergic receptors, effectively inhibited vanadate-induced Ca2+ mobilization, but surgical sympathectomy was without effect. This is the first demonstration of vanadate mimicking a-adrenergic agonists in vivo. |
| Databáze: |
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| Externí odkaz: |
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