| Autor: |
Magrini, Alberto, Guerrisi, Maria, Pavoni, Pietro, Concolino, Giuseppe, Mango, Lucio |
| Zdroj: |
European Journal of Nuclear Medicine and Molecular Imaging; June 1980, Vol. 5 Issue: 3 p247-255, 9p |
| Abstrakt: |
Adrenal uptake of 131I-19 cholesterol, administered intravenously, was studied in five normal volunteers and in five patients with various adrenal diseases. Daily counts over the adrenal area and over the lumbar column area (assumed to be representative of blood activity) were performed for 15–20 days after administration of the tracer. Data obtained were analyzed with a three-pool model (two blood pools and one adrenal pool) which enabled us to take into account the influence of extraadrenal cholesterol metabolism on adrenal uptake and to correct the blood activity in the adrenal area more accurately. The dynamic study of adrenal function with the compartmental analysis proposed in the present study provides information not only on the plasma cholesterol metabolic parameters, but also on the adrenal cholesterol uptake and adrenal cholesterol output. Information on plasma cholesterol metabolic parameters is extremely useful because adrenal cholesterol metabolism can be studied in an observation period of less than 30 days, i.e., before commencement of the true clearance curves of cholesterol from the adrenals. From the results obtained it was found that the adrenal output rates give information on the physiology and on the physiopathology of each adrenal. The relative turnover rate, in fact, in all cases of hyper-adrenocorticism examined was about 2 to 100 times higher than the maximum value observed in normal subjects. The study proposed seems more specific than those based on the qualitative evaluation of adrenal images or on the simple determination of the maximum percent uptake. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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