Anti H-2Dd alloreactivity mediated by herpes-simplex-virus specific cytotoxic H-2k T lymphocytes is associated with H-2Dk

Autor:	Pfizenmaier, Klaus, Jung, Hartmut, Kurrle, Roland, Röllinghoff, Martin, Wagner, Hermann
Zdroj:	Immunogenetics; February 1980, Vol. 10 Issue: 1-4 p395-404, 10p
Abstrakt:	Herpes-simplex-virus (HSV) specific, H-2k-restricted, immune cytotoxic T lymphocytes also lyse noninfected H-2d target cells. Genetic mapping studies revealed that HSV-specific Dk-restricted CTL cross-react with allogeneic targets expressing Dd alloantigens. Cold target inhibition experiments indicate that only a minority of HSV-specific CTL mediate cross-reactive cytolysis. The data give an example of where the phenomenon of H-2-restricted versus nonrestricted responsiveness is not due to distinct subsets of T cells but solely depends on the antigenic determinants recognized.
Databáze:	Supplemental Index
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