| Autor: |
Payan, Iris L., Chou, Shou-Jian, Fisher, George H., Man, Eugene H., Emory, Carolyn, Frey, William H. |
| Zdroj: |
Neurochemical Research; February 1992, Vol. 17 Issue: 2 p187-191, 5p |
| Abstrakt: |
Normal protein-boundl-aspartyl/l-asparaginyl residues may undergo post-translational modification by racemization tod-aspartate, or by isomerization to thel-isoaspartyl form in which the peptide chain links through the beta carboxyl group of the residue. Based on preliminary results reported here, proteins associated with Alzheimer neurofibrillary tangle preparations contain a significantly greater number of these modified aspartyl residues than the unaffected proteins from the surrounding gray matter or in comparable preparations from normal brains. |
| Databáze: |
Supplemental Index |
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