| Autor: |
Chauncey, Depew M., Hagan, Phillip L., Halpern, Samuel E., McKegney, Martha L., Bernstein, Kristopher E. |
| Zdroj: |
European Journal of Nuclear Medicine and Molecular Imaging; December 1978, Vol. 3 Issue: 4 p243-248, 6p |
| Abstrakt: |
The distribution of cadmium-115m chloride, cobalt-57 bleomycin, selenium-75 selenite, selenium-75 selenomethionine and iodine-125 human serum albumin was investigated in rats bearing thigh implanted Morris 7777 hepatomas. Viable and nonviable tumor tissue were collected in order to determine the relative affinities of these radiopharmaceuticals for these tissues. Groups of animals were sacrificed at 4, 24, 48, 72 and 96 h following injection. Viable tumor-to-blood and muscle ratios for cadmium-115m chloride and cobalt-57 bleomycin were higher than those for gallium-67 bitrate at 4 h post-injection. The unusually high cobalt-57 bleomycin ratios for both viable and nonviable tumor were the result of very low muscle and blood values rather than high tumor uptake. Tumor-to-background ratios for iodine-125 human serum albumin, selenium-75 selenomethionine and selenium-75 selenite were inferior to those derived for cobalt-57 bleomycin or gallium-67 citrate. None of the agents included in this study compared well with gallium-67 citrate as a tumor localizing agent with the possible exception of cadmium-115m chloride and coblat-57 bleomycin at early time periods. As in most other radiopharmaceuticals studied in this model, a reversal occurred in the viable-to-nonviable tumor ratios as the time after injection increased. |
| Databáze: |
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| Externí odkaz: |
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