| Autor: |
Luderer, Albert A., Passmore, Howard C. |
| Zdroj: |
Immunogenetics; December 1976, Vol. 3 Issue: 1 p277-287, 11p |
| Abstrakt: |
Immunization of inbred mouse strains lacking the Slp allotype results in the production of Slp antibodies in some strains but elicits no detectable response in other strains. Analysis of standard inbred and congenic resistant strains reveals that both the qualitative and quantitative ability to respond to the Slp allotype is associated with theH-2 haplotype of the recipient. Three different response phenotypes can be identified utilizing complement fixation and quantitative immunodiffusion tests. Strains which carry theH-2q haplotype are high responders,H-2k strains are intermediate in response, whileH-2b andH-2v strains produce no detectable antibody. The characteristic response patterns of high and intermediate responders were manifest by day 35 of immunization and continued as discrete response types after a second booster. Quantitative data in the immune response of the intra-H-2 recombinant B10.A(4R) suggest that the recombination event which established theH-2h4 chromosome disturbs the proper function of the genetic determinant controlling response to Slp. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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