Development of [3H]muscimol binding to subcellular particles of a culture of mouse brain

Autor:	Sarliève, L. L., DeFeudis, F. V., Ossola, L., Varga, V., Mandel, P.
Zdroj:	Neurochemical Research; December 1980, Vol. 5 Issue: 12 p1279-1290, 12p
Abstrakt:	“Specific” binding of [3H]muscimol (11.5 nM), related to GABA receptors, occurred in subcellular particles prepared from 4-, 8-, and 12-day cultures of embryonic (14-to 15-day-old) mouse cerebrum, but not to particles prepared from 20-to 45-day cultures. Phase-contrast microscopy revealed that the presence of neuronal elements (neuroblasts, neurites) paralleled the binding of [3H]muscimol. Further evidence is thus provided for using high-affinity [3H]muscimol binding as a “neuronal marker.”
Databáze:	Supplemental Index
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