The ADR-01 dialysis device with dialyzate regeneration: Design and results of preliminary testing

Autor: Grinval'd, V., Khaitlin, A., Éventov, V., Maksimenko, V., Noskov, S., Yashkin, V., Yakovleva, A., Savrikov, E.
Zdroj: Biomedical Engineering; May 1993, Vol. 27 Issue: 3 p151-156, 6p
Abstrakt: Conclusions: 1. The ADR-01 dialysis device with the DIP-02-02 dialyzer (1 m2 of “kuprofan” membrane, 500 ml/min perfusate flow rate) under recirculation mode and electrochemical regeneration of 3 liters of perfusate during 3.5–4 h operation provides reduction of concentration of urea and creatinine by 40–60% with the average flow rate of not less than 8 g/h. Such reduction of concentration corresponds to the efficiency of dialysis devices with dialyzate discharge of 100–120 liters per dialysis procedure. The 30–40-fold reduction of dialyzate volume eliminates the necessity for complex, bulky, expensive, and scarce auxiliary equipment for preparation of water and concentrate. 2. During electrochemical regeneration, the ionic content and pH of the perfusate remain practically unchanged: deviation in ion concentrations from their initial levels do not exceed 10%. The KU 2 8 chS cationite (sodium form), or klinoptilalite, or their combination is used for removing excessive potassium. With total volume of the sorbents of 0.3–0.5 liters, the average rate of potassium removal is not less than 0.5 g/h. 3. The small volume of dialyzate (only 3 liters) and the opportunity for using the usual non-sterile saline solution as the dialyzate increase the independence of dialysis equipment, simplify its clinical application, and improves the physiological background of dialysis. Dialysis with dialyzate regeneration allows the use of acetate to be avoided, and it can be considered as an alternative for bicarbonate dialysis.
Databáze: Supplemental Index
Externí odkaz: