| Autor: |
Jongeneelen, F. J., Anzion, R. B. M., Leijdekkers, Ch.-M., Bos, R. P., Henderson, P. Th. |
| Zdroj: |
International Archives of Occupational and Environmental Health; November 1985, Vol. 57 Issue: 1 p47-55, 9p |
| Abstrakt: |
Summary A method for isolating 1-hydroxypyrene from urine is described. The presence of 1-hydroxypyrene in urine was identified by fluorescence excitation and emission scanning after HPLC-separation. 1-Hydroxypyrene could be detected in the urine of rats following oral administration of as little as 0.5 µg pyrene. The dose-dependence of 1-hydroxypyrene in urine was evident after a wide range of pyrene dosing. After therapeutical coal tar treatment of dermatological patients the enhanced excretion of 1-hydroxypyrene was highly significant. Employees of a creosote impregnating plant showed an excretion pattern of 1-hydroxypyrene which could be related to their work. 1-Hydroxypyrene in urine of non-exposed people was very low, but detectable. It is suggested that the method reported is suitable for the assessment of uptake of man to pyrene, a compound that is commonly present in work environments which are associated with pollution of polycyclic aromatic hydrocarbons. |
| Databáze: |
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