| Autor: |
Sollertinskaya, T. N., Nuritdinov, É. N., Obukhova, M. F. |
| Zdroj: |
Neuroscience and Behavioral Physiology; September 1993, Vol. 23 Issue: 5 p459-469, 11p |
| Abstrakt: |
Data are presented in this paper regarding the influence of the opioid peptide, dermorphin, and its conjugate on the conditioned reflex activity of sousliks. The administration of dermorphin (0.1 µ/g, subcutaneously) is accompanied by a fall in body temperature, slowing of the baseline vegetative indices, and the sinking of the animal into a sleep-like state. A substantial disturbance of conditioned reflex activity was identified in the late period (delayed effects). Immunization of the hibernating sousliks with a conjugate of dermorphin leads to a gradual awakening of the animals from hibernation, to the normalization of conditioned reflex activity, and to the appearance of the motoric component of a conditioned defense reaction. The question of a possible specific role of dermorphin in the mechanisms of hibernation is discussed. |
| Databáze: |
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