| Autor: |
Baranov, V. G., Savchenko, O. N., Propp, M. V., Proimina, F. I., Korneev, G. Ya., Strel'tsova, N. A., Danilova, O. A. |
| Zdroj: |
Neuroscience and Behavioral Physiology; September 1985, Vol. 15 Issue: 5 p404-407, 4p |
| Abstrakt: |
Conclusions 1.In male rats the neonatal injection of estradiol exerts a much stronger injurious effect on the mechanisms of sexual function than the injection of testosterone, causing a decline in the synthesis and release of luliberin, LH, and testosterone and a reduced sex-organ mass, resulting in 100% sterility of the animals.2.The testosterone doses damaging sexual function after neonatal injection are much higher for males (1,000 µg per animal) than for females (15–25 µg). Consequently, the break-down of the regulation of tonic LH release requires the action of a much larger amount of testosterone than for the disruption of the mechanisms of the cyclic secretion of gonadotropins.3.The action of sex hormones injuring sexual function after injection in newborn male rats is probably localized at the hypothalamic level; there is no loss of hypophyseal sensitivity to luliberin. |
| Databáze: |
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