Expression of galactose-1-P-uridyltransferase in Chinese hamster × human galactosemia somatic cell hybrids

Autor: Sparkes, Robert S., Mohandas, T., Sparkes, Maryellen C., Shulkin, Jeffery D.
Zdroj: Biochemical Genetics; August 1979, Vol. 17 Issue: 7-8 p683-692, 10p
Abstrakt: Lymphocytes from a patient with classic galactosemia (GALT deficiency) were hybridized with a Chinese hamster cell line. Electrophoretic evaluation of GALT in 31 independently derived interspecific hybrid clones failed to demonstrate expression of the human GALT gene even when human chromosome 9 was present. Possible mechanisms for this lack of expression are presented.
Databáze: Supplemental Index