A gene apparently determining the extent of sialylation of lysosomal α-mannosidase in mouse liver

Autor: Dizik, Mark, Elliott, Rosemary W.
Zdroj: Biochemical Genetics; February 1977, Vol. 15 Issue: 1-2 p31-46, 16p
Abstrakt: Organ-specific electrophoretic heterogeneity of lysosomal a-mannosidase has been observed within individual strains of inbred mice. Polymorphism between C57BL/6J and CBA/J for liver lysosomal a-mannosidase is determined by a single genetic locus on chromosome 5 and appears to be the result of differences in sialylation of the lysosomal enzyme. Two different patterns of expression of development of the liver electrophoretic forms have been observed.
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