| Autor: |
Russell, Elizabeth S., Blake, Sharon L., McFarland, Eleanor C. |
| Zdroj: |
Biochemical Genetics; December 1972, Vol. 7 Issue: 3-4 p313-330, 18p |
| Abstrakt: |
In a survey of mice from 40 inbred strains, largely previously untested, four alleles were distinguished at the Hba locus, determining structure of adult mouse hemoglobin a chain. This finding supports and extends previous sequence studies by others. Methods are given by which each phenotype was characterized by its solubility profile at varying pH and by its chromatography pattern. Concordance was complete between histidine-positive aT-4 (defining Hbac) and high-intermediate solubility profile. In three inbred strains, a distinct new low-solubility profile, not associated with his-positive aT-4, was recognized, and mice with this phenotype were classified as Hbad. Implications of observed widely distributed four-allele polymorphism of mouse hemoglobin a-chain structure are discussed. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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