| Autor: |
Bleavins, Michael R., Hinsdill, Ronald D., Hsia, M. T. Stephen, Meisner, Lorraine F., Wiley, John E. |
| Zdroj: |
Archives of Environmental Contamination and Toxicology; November 1985, Vol. 14 Issue: 6 p677-684, 8p |
| Abstrakt: |
The effects of chronic dietary exposure to 3,3',4,4'-tetrachloroazoxybenzene (TCAOB) on the reproductive efficiency of female Swiss-Webster mice were measured. The immunocompetence of their offspring was assayed at weaning. No indications of toxicosis were seen in the adult females with the exception of a reduction in the thymus weight of the animals consuming 10 ppm TCAOB. Pup mortality to weaning and the percentage of females whelping were not affected by 0.1 ppm, 1 ppm, or 10 ppm of TCAOB in the diet. There was, however, a significant reduction in the number of pups (at birth and at weaning) per female whelping at 10 ppm TCAOB in the diet. The thymus weight and plaque-forming-cell response of the pups were also significantly reduced below control levels. The lymphocyte blastogenic response to Concanavalin-A and lipopolysaccharide, and total peripheral blood leukocyte count, were not affected by the concentrations of TCAOB tested. Dietary treatment of female mice with relatively high concentrations of this chemical resulted in reduced reproductivity capacity, but only moderate immuno-suppression of their offspring exposed duringin utero and early postnatal development. |
| Databáze: |
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