| Autor: |
Villeneuve, D. C., Phillips, W. E. J., Panopio, L. G., Mendoza, C. E., Hatina, G. V., Grant, D. L. |
| Zdroj: |
Archives of Environmental Contamination and Toxicology; September 1974, Vol. 2 Issue: 3 p243-252, 10p |
| Abstrakt: |
Male and female rats were raised from weaning on diets containing 0, 20, and 40 ppm of hexachlorobenzene (HCB) for three months. The animals were then placed on an HCB-free diet and dosed with either sodium phenobarbital or carbon tetrachloride. Animals were killed at 0, 15, and 30 days on the HCB-free regimen and tissue residues determined. Plasma cholinesterase activity was depressed by carbon tetrachloride treatment as were liver aniline hydroxylase andN-demethylase activities. Phenobarbital treatment increased liver aniline hydroxylase andN-demethylase activities. HCB decay profiles were established for plasma, fat, and liver. No direct correlation was observed between induction of enzyme activity and rate of disappearance of HCB residues in liver tissue. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
|
Full text from SpringerLink