| Autor: |
Termond, E. F. S., Zonnenberg, B., Winograd, B., Oosterbaan, M. J. M., van der Kleijn, E., Vree, T. B. |
| Zdroj: |
Pharmacy World & Science; August 1985, Vol. 7 Issue: 4 p158-162, 5p |
| Abstrakt: |
In oncochemotherapy with methotrexate (MTX) a peripheral concentration >0.45 mg/l and a plasma concentration <45 mg/l must be maintained for 20 h. The time periods required to reach and maintain steady-state concentrations after tapered and linear intravenous infusion were compared. Pharmacokinetic analyses according to a two-compartment model were used to calculate dosage regimens and concentration profiles by means of the Bayesian General Modelling Program (BM) and NONLIN. When the dosage regimen is based on a steady-state concentration in the peripheral compartment (which is the target compartment for MTX) tapered infusion reaches this concentration 40% faster and maintains it 12.5% longer, but no difference is found if the dosage regimen is based on a steady-state concentration in the central compartment. In theory the two-step 24-hour tapered infusion can be replaced by a bolus injection plus linear infusion in the ratio 1∶2 of the total dose. These dosage regimens are to be preferred over linear infusion. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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