| Autor: |
Voronin, L. L., Gusev, A. G., Mityushkin, M. V. |
| Zdroj: |
Neurophysiology; March 1990, Vol. 22 Issue: 2 p162-169, 8p |
| Abstrakt: |
Amplitude distributions of postsynaptic potentials subject to binomial distribution were simulated in computer-based experiments. Effects of sample size (N) and standard deviation of noise (Sn) on accuracy of determining mean quantal content (m) and quantal value (v) were investigated using four quantal analysis techniques (histograms, variation coefficient, failure and combined techniques). It was found that m and v may be determined fairly accurately (to within 10%) at Sn<2v using the last three techniques mentioned and at Sn=v (where N=500–1000). It is possible to obtain similar results for N=50–200 if the experiment is repeated ten times. The possibility of applying such techniques to actual physiological results was confirmed by analyzing an extensive trace (N=1333) of inhibitory postsynaptic potentials in sensorimotor cortex units of unanesthetized rabbits. |
| Databáze: |
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