Antigenic similarity between cytoplasmic tetrodotoxin-sensitive protein and neuronal membrane proteins

Autor: Malysheva, M. K., Lishko, V. K., Zhukareva, V. A., Gerasimenko, O. V.
Zdroj: Neurophysiology; July 1989, Vol. 21 Issue: 4 p347-351, 5p
Abstrakt: Membrane proteins with a molecular weight of 290, 180, and 55 kDa were isolated using immunosorbent attached to sepharose and rabbit antibodies to cytoplasmic tetrodotoxin-sensitive protein from beef brain gray matter. A technique used for research into voltage-dependent sodium channels was applied to reconstruction of these proteins and investigation of toxin-dependent sodium flows through the lipoprotein membrane. Findings are interpreted as evidence of the similarity between cytoplasmic tetrodotoxin-sensitive protein and that of sodium channels at the cell membrane.
Databáze: Supplemental Index