Role of active ion transport in reception of the generator potential of the isolated frog muscle spindle

Autor: Alekseev, N. P., Pavlenko, I. N.
Zdroj: Neurophysiology; July 1975, Vol. 7 Issue: 4 p323-327, 5p
Abstrakt: The effect of complete replacement of sodium ions by lithium ions in Ringer's solution and of 10-4 M ouabain on the receptor potential of the isolated frog muscle spindle was investigated. Initially, under the influence of lithium ions and ouabain, the hyperpolarization phase of this potential diminished and disappeared, and later the same fate befell the static and dynamic part of its depolarization phase. The rise time of the receptor potential was increased in a solution containing lithium ions but in the solution with ouabain it remained the same as initially. No appreciable changes were found in the rate of fall of the dynamic part of the depolarization phase. On rinsing the muscle spindle in normal Ringer's solution in the experiment with lithium ions recovery was incomplete, and in the experiments with ouabain the receptor responses were not restored.
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