Immunofluorescent localisation of calcitonin in medullary (C Cell) thyroid carcinoma, using antibody to the pure porcine hormone

Autor:	Bussolati, G., Foster, G. V., Clark, M. B., Pearse, A. G. E.
Zdroj:	Virchows Archiv B Cell Pathology Zell-pathologie; December 1969, Vol. 2 Issue: 1 p234-238, 5p
Abstrakt:	In spite of considerable differences in the amino-acid sequences of human and porcine calcitonin, cross reactivity is demonstrable, by indirect immunofluorescence, between human C cells and porcine antibody. In a medullary carcinoma of the thyroid, removed from a 19-year old female, about 40% of the tumour cells contained calcitonin. The hormone was present not only in the cytoplasm but also, in many instances, in the nucleoli. This latter finding has not been observed by us, or reported by others, in normal C cells from any animal species.
Databáze:	Supplemental Index
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