| Autor: |
D'Onofrio, Chiara, Pesce, Caterina D., Fontana, Tecla, Ciprani, Fabrizio, Bonmassar, Enzo, Calio, Raffaele |
| Zdroj: |
Cancer Immunology, Immunotherapy; July 1990, Vol. 31 Issue: 4 p213-220, 8p |
| Abstrakt: |
Summary Infection with human T-cell leukemia virus type I (HTLV-I) is associated in vitro and in vivo with a remarkable depression of cell-mediated immune functions. In the present report it is shown that early events following virus-induced suppression of the cell-mediated immune response of freshly isolated cord blood mononuclear cells (CBL) infected with HTLV-I can be partially counteracted by treatment with interferons a, ß or ? (IFN). All three types of IFN exerted a protective effect on CBL cultures exposed to the virus. This resulted in: (a) a reduced number of virus-positive cells until 4 weeks of culture; (b) delay in the clonal expansion of infected cells (IFNa and ?); (c) increased natural killer cell activity of CBL, 1 week post-infection (p.i.), mediated by IFN?; (d) increase of allospecific recognition of infecting and priming HTLV-I donor MT-2 cells by CBL in a cytotoxic-T-lymphocyte-like response, mediated by IFN and particularly by IFN?; (e) phenotype distribution of CBL subpopulations, tested 4 days p.i., more similar to that of non-infected CBL cultures. |
| Databáze: |
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