Distribution of intact and Fab12 fragments of anti-human chorionic gonadotrophin antibodies in nude mice bearing human choriocarcinoma xenografts

Autor: Searle, Frances, Adam, Theresa, Boden, Joan A.
Zdroj: Cancer Immunology, Immunotherapy; April 1986, Vol. 21 Issue: 3 p205-208, 4p
Abstrakt: A direct comparative study of the distribution of intact and Fab12 fragments of mouse monoclonal anti-human chorionic gonadotrophin antibody, W14A, in nude mice bearing a human choriocarcinoma xenograft, indicates that the tumour:blood ratio is generally improved with fragments. Some parameters which may determine the distribution are outlined.
Databáze: Supplemental Index