| Autor: |
Steinbok, P., Mahaley, M. S., Lipper, S., Dalzell, Juanita G., Pegram, C., Bigner, D. |
| Zdroj: |
Cancer Immunology, Immunotherapy; April 1980, Vol. 8 Issue: 1 p55-59, 5p |
| Abstrakt: |
Five-day-old Fischer 344 rats were inoculated intracerebrally with BCG cell walls attached to oil (BCG-CW) or with oil emulsion alone. Doses of BCG-CW of 40 µg in 0.01 ml, 200 µg in 0.05 ml, and 400 µg in 0.1 ml were used, with similar volumes of oil emulsion for comparison. Twentyfive days later hydrocephalus, intracerebral granulomas, and arachnoid granulomas were found at autopsy. The frequency and severity of these abnormalities were related to the presence of BCG-CW in the inoculum and the dose administered. There were minimal abnormalities with 40 µg BCG-CW. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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