| Autor: |
Bartlett, G. L., Katsilas, D. C., Kreider, J. W., Purnell, D. M. |
| Zdroj: |
Cancer Immunology, Immunotherapy; April 1977, Vol. 2 Issue: 2 p127-133, 7p |
| Abstrakt: |
Injection of vaccines containing BCG and irradiated L10 hepatoma cells into strain 2 guinea pigs led to arrest and regression of viable L10 cells injected contralateral to and simultaneous with the vaccine. If the tumor cells in the vaccine had been stored in LN2, the vaccine was significantly less effective. The diminished immunogenicity of the stored cells could not be attributed to the sequence of freezing and irradiation, nor to the presence of dead cells which had been killed during cryopreservation. We concluded that cells which had been stored in LN2 had undergone changes which decreased their immunogenicity but which did not alter permeability to trypan blue. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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