Copper status in rats fed diets supplemented with either vitamin E, vitamin A, or β-carotene

Autor: van den Berg, Gerrit J., Lemmens, Arnoldina G., Beynen, Anton C.
Zdroj: Biological Trace Element Research; May 1993, Vol. 37 Issue: 2-3 p253-259, 7p
Abstrakt: Copper status was measured in rats fed copper-adequate, purified diets supplemented with either vitamin E (250 IU/kg), vitamin A (40,000 IU/kg), or β-carotene (2 g/kg). It was hypothesized that the extra intake of the antioxidants would spare vitamin C resulting in a decreased copper status as shown previously after supplementation with vitamin C. A significant increase in plasma ascorbate concentration was observed after β-carotene supplementation, but not after supplemental vitamin E or vitamin A. Extra intake of either β-carotene or vitamin A slightly, but significantly, raised plasma copper concentrations. β-carotene also slightly raised liver copper concentration. Supplemental vitamin E had no effect on plasma and liver copper concentrations. It is concluded that the observed relatively small effects of supplemental vitamin A and β-carotene on copper status in rats are not mediated by changes in plasma vitamin C concentration.
Databáze: Supplemental Index